You can find a complete winstrol – stanozolol profile at:

http://www.winstrol.info/1/winstrol-profile/

As I stated before winstrol is the well known brand of stanozolol, but in the recent years another brand from British Dragon has become notorious as well. This pharmaceutical laboratory carries a wide range of anabolic steroids of the highest purity.

British Dragon also implemented very strict procedures for authenticating and establish as genuine the different distributors they approved. You can check it out at:

http://www.britishdragon.com/sellers/index.php

Probably two of the most know British Dragon products containing stanozolol are:

• 
  Stanabol 10 - Winstrol – Stanazolol
   
• 
  Stanabol 10 - Winstrol – Stanazolol

Leptin is the product of the product of the obesity gene. Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including the regulation (decrease) of appetite and metabolism. Leptin is also an adiposity signal. To date, only leptin and insulin fulfill the criteria of an adiposity signal:

Due it circulates at levels proportional to body fat.
Because it enters the central nervous system (CNS) in proportion to its plasma concentration.
Due its receptors are found in brain neurons involved in regulating energy intake and expenditure.

Study of Journal of Endocrinology, Vol 160, Issue 3, 425-432 showed that circulating leptin levels are higher in women than in men, even after correction for body fat. This gender-based difference may be conditioned by differences in the levels of androgenic hormones. To explore this possibility, a systematic in vitro study with organ cultures from human omental adipose tissue, either stimulated or not with androgens (1 microM), was undertaken in samples obtained from surgery on 44 non-obese donors (21 women and 23 men). The assay was standardized in periods of 24 h, ending at 96 h, with no apparent tissue damage. Leptin results are expressed as the mean+/-s.e.m. of the integrated secretion into the medium, expressed as ng leptin/g tissue per 48 h. Spontaneous leptin secretion in samples from female donors (4149+/-301) was significantly higher (P<0.01) than that from male donors (2456+/-428). Testosterone did not exert any significant effect on in vitro leptin secretion in either gender (4856+/-366 in women, 3322+/-505 in men). Coincubation of adipose tissue with dihydrotestosterone (DHT) induced a significant (P<0.05) leptin decrease in samples taken from women (3119+/-322) but not in those taken from men (2042+/-430). Stanozolol, a non-aromatizable androgen, decreased (P<0.05) leptin secretion in female samples (2809+/-383) but not in male (1553+/-671). Dehydroepiandrosterone sulphate (DHEA-S) induced a significant (P<0.01) leptin decrease in female samples (2996+/-473), with no modifications in samples derived from males (1596+/-528). Exposure to androstenedione also resulted in a significant reduction (P<0.01) of leptin secretion in samples taken from women (2231+/-264), with no effect on male adipose tissue (1605+/-544). In conclusion, DHT, stanozolol, DHEA-S and androstenedione induced a significant inhibition of in vitro leptin secretion in samples from female donors, without affecting the secretion in samples from men. Testosterone was devoid of activity in either gender.

Question: “If an athlete uses the anabolic steroid called stanozolol, what is the window of detection for the presence of stanozolol or its metabolites in the body?
 
What I am trying to ask is, how long after the injection, can we expect to find traces of the anabolic steroid stanozolol, or its metabolites, in the human body? 
 
It is important to note that I am inquiring only about intramuscular injection as opposed to oral administration (pill), because the latter usually is excreted by the body much faster.”

Response: “There is not enough information concerning detection rates for injected Stanozolol (AKA Winstrol). This kind of data is elusive in the conventional literature.
 
The detection rates noted for injectable Winstrol vary with the source. However, I have found references for detection rates that exceed 3 months. An article written by Ben Johnson’s coach actually mentioned detection rates as high as 13 months!! Unfortunately, there is no scientific citation to back up his statement and there is no authoritative backup for the rates mentioned in other sources, except for the first reference noted by Di Pasquale from a 1992 article.
 
References to detection rates of three to five months seem to be the most common.

Answer: Sometime in the future I’m going to create a permanent fixture to AE called the questions that would not die. For the record, both stanazolol (Winstrol) and methandrostenolone (Dianabol) can be taken orally and via IM injection as both of them have the same c17 methylation. And it’s perfectly acceptable to take the injectable version of each of these products and use them orally.

Generally the injectable version of Winstrol is considered to be more effective than the oral. Quite frankly, neither is more effective than the other, it’s simply a case where the injectable form of Winstrol is a 50 mg/ml preperation, and oral stanazolol tablets are 2 mg each. Since it’s common for a male bodybuilder to use 1 ml of stanazol per day, but uncommon for them to use 25 Winstrol tabs a day, the difference in effectiveness is entirely due to the fact that injectable users consume more drug the oral users.

The only other difference between the two routes of administration is the injection will avoid the first pass through the liver. Consequently, oral use of stanazolol is slightly more hepatotoxic than injectable use. However, even 17-AA steroids like stanazolol rarely raise liver enzymes to levels that might cause concern, even after prolonged use, and the convenience of daily oral use should outweigh any concern you have over liver health. Personally, if I were using stanazolol, I’d use an injectable formulation orally every day, and simply have blood work periodically to ensure that my liver wasn’t experiencing an inordinate amount of stress.

Oral anabolic steroids produce striking reductions in serum concentrations of high-density lipoprotein (HDL) cholesterol. We hypothesized that this effect related to their route of administration and was unrelated to their androgenic potency. We administered oral stanozolol (6 mg/d) or supraphysiological doses of intramuscular testosterone enanthate (200 mg/wk) to 11 male weight lifters for six weeks in a crossover design. Stanozolol reduced HDL-cholesterol and the HDL2 subfraction by 33% and 71%, respectively. In contrast, testosterone decreased HDL-cholesterol concentration by only 9% and the decrease was in the HDL3 subfraction. Apolipoprotein A-I level decreased 40% during stanozolol but only 8% during testosterone treatment. The low-density lipoprotein cholesterol concentration increased 29% with stanozolol and decreased 16% with testosterone treatment. Stanozolol, moreover, increased postheparin hepatic triglyceride lipase activity by 123%, whereas the maximum change during testosterone therapy (+25%) was not significant. Weight gain was similar with both drugs, but testosterone was more effective in suppressing gonadotropic hormones. We conclude that the undesirable lipoprotein effects of 17-alpha-alkylated steroids given orally are different from those of parenteral testosterone and that the latter may be preferable in many clinical situations.

What gains can I expect from winstrol | stanozolol use?

Well, winstrol gains are very well known. Winstrol is a very popular anabolic androgenic steroid. You can find it in oral or injectable form. It ranks up as one of the most widely used anabolic drug by competitive athletes and bodybuilders.

Winstrol has a short active life of around 8 hours. This quality of short life affects the way you must use it and the gains you can obtain from it. The injectable version of Stanozolol is known to give more results compared to the oral form. At the same level of dosages, the oral variety is less effective than the injectable one. The reason is clear oral stanozolol must be broken down upon first pass metabolism in the liver, which makes it difficult for the blood to absorb an equal amount of the substance.

Winstrol normally provide fast gains in muscularity. It is not a steroid designed for mass purposes, but increases notably the muscle appearance and activates the fat loss process. The reason for fast winstrol gains is due to its short active life and combined with a greater frequency of injection or oral consumption, results are fairly fast.

Besides, winstrol is not capable of converting into estrogen, therefore the use of antiandrogenics is not required. Winstrol also inhibits progestagenic effects. Progesterone does play a role in the development of gynecomastia. The reason is because progesterone can aggravate estrogenic side effects by agonizing estrogen and it also plays a role in gynecomastia.

Due winstrol is used mainly to lose fat, it would be a great idea to combine stanozolol with a non aromatizing steroids such as trenbolone or halotestin. This combination can provide you a strongly defined, hard look.

As you can see these are the gains you can expect from winstrol use.

Stanozolol can be used in bodybuilding, typically “stacked” with other testosterone-based anabolic steroids. Stanozolol is liked by many due to the fact it causes strength increases without excess weight-gain, promotes increases in vascularity, and will not convert to estrogen. It also does not cause excess water retention, and even sometimes is thought to have a diuretic effect on the body. If you compete at high level an orine test is mandatory. But how scientists find out that you have really used anabolic steroids?

For example, You can read about this specific method: screening for anabolic steroids in doping analysis by liquid chromatography/electrospray ion trap mass spectrometry. This study was published by Biomed Chromatogr. 2006 May;20(5):429-33.

A fast and selective LC/MS/MS method for the screening of four anabolic steroids in human urine has been developed and validated. Liquid-liquid extraction with diethyl ether was applied after enzymatic hydrolysis. Analyses were performed on an ion trap mass spectrometer equipped with electrospray ionisation. MS/MS was applied for all compounds. The analytical run time was 11 min. The LOD for all compounds varied between 1 and 10 ng/mL. Left-over A samples, which were declared positive by GC/MS for the presence of 3′-hydroxystanozolol, were assessed using the described method.

Read more at: PubMed

Two different forms

We should point out that there are really two forms of Stanozolol available, oral and Injectable (called Depot).The injectable version of the drug is considered safer and more effective than the oral version. Unlike other injectable steroids, however, Winstrol Depot must be injected more frequently as it’s dissolved in water. Oil-based injectables tend to last longer in the body, which means fewer injections are needed. Another reason why injectable winstrol is preferred over oral is that it doesn’t easily convert (called aromatization) into estrogen hormones. Not only does this reduce the chances of developing gynecomastia (swelling of the breast tissue in men), but also water retention is kept to a minimum. This last characteristic makes Stanozolol popular as a pre-contest bodybuilding drug (Stanozolol is also used during the off-season as it does produce good muscle gains).

The risks

Like all oral steroids oral Winstrol has been modified at its 17th carbon position to help it survive passage through the digestive system and liver. Ironically it’s this chemical tweaking that makes the drug more damaging to the liver. For those who do decide to use oral Winny tablets, we strongly urge you to have a physician keep a close eye on your liver enzyme values with regular blood tests.

Even though it’s less common, the possibility of developing liver problems cannot be excluded from the injectable versions of the drug. While it does not enter the body through the liver, it still travels through it with each pass through the circulatory system. So over time there is a lower level of stress.

It should also be noted that both versions of Winny have been linked to significant changes in cholesterol levels. This negative effect is common with steroids in general – even medical therapy – so it can become a health concern if the individual stays on the drug for extended periods of time. Since the oral version will probably have a greater effect on cholesterol levels than the injectable form because of both the method of administration and chemical modification, individuals should try to limit its use.

Think Smart!

As you can see Stanozolol is not some super wonder bodybuilding drug that is risk free. In fact the risks have to be taken in consideration. I recommend you go immediately to (www.1st-Anabolic.com) fill in the opt-in form and download the underground report. It is an extraordinary report with no filler, no BS, just good information right to the meat.

There is evidence that anabolic steroids, which are derived from testosterone and have markedly less androgenic activity, promote tissue growth and enhance tissue repair; however, the mechanisms involved in their anabolic activities remain unclear.

In this article, scientists measured the effect of the anabolic steroid stanozolol on cell replication and collagen synthesis in cultures of adult human dermal fibroblasts. Stanozolol (0.625-5 microg per ml) had no effect on fibroblast replication and cell viability (p = 0.764) but enhanced collagen synthesis (p < 0.01) in a dose-dependent manner (r = 0.907). Stanozolol also increased (by 2-fold) the mRNA levels of alpha1 (I) and alpha1 (III) procollagen and, to a similar extent, upregulated transforming growth factor-beta1 (TGF-beta1) mRNA and peptide levels (p < 0.001). There was no stimulation of collagen synthesis by testosterone.

The stimulatory effects of stanozolol on collagen synthesis were blocked by a TGF-beta1 anti-sense oligonucleotide, by antibodies to TGF-beta, and in dermal fibroblast cultures derived from TGF-beta1 knockout mice. We conclude that collagen synthesis is increased by the anabolic steroid stanozolol and that, for the most part, this effect is due to TGF-beta1. These findings point to a novel mechanism of action of anabolic steroids.